Overview of Diethylstilbestrol (DES)

Diethylstilbestrol (DES) is a synthetic form of the hormone estrogen that was prescribed to pregnant women from the 1940s until the early 1970s to prevent pregnancy complications. However, it was later discovered that DES exposure had significant health implications.

Diethylstilbestrol (DES)

Health Risks Associated with DES Exposure

• For Mothers: Women who took DES may have an increased risk of breast cancer and other reproductive health issues.

• For Daughters: Female offspring exposed to DES in utero may experience a range of health problems, including:

  • Clear cell adenocarcinoma of the vagina and cervix

  • Structural abnormalities of the reproductive tract

  • Infertility and pregnancy complications

• For Sons: Male offspring may face risks such as:

  • Testicular abnormalities

  • Increased risk of certain cancers

  • Reproductive health issues

Current Understanding and Recommendations

Due to the risks associated with DES, it is no longer prescribed to pregnant women. Those who were exposed to DES are encouraged to:

• Inform their healthcare providers about their exposure history.

• Engage in regular health screenings, particularly for cancers associated with DES.

• Discuss any reproductive health concerns with their doctors.

Conclusion

Exposure to diethylstilbestrol (DES) has significant and lasting health implications for both mothers and their offspring. Awareness and proactive health management are crucial for those affected.